Pathways for Catalysis

Thiophene hydrodesulfurization catalysis on supported Ru clusters: Mechanism and site requirements for hydrogenation and desulfurization pathways

Kinetic and isotopic methods were used to probe elementary steps and site requirements for thiophene hydrogenation and desulfurization on Ru metal clusters. Turnover rates for these reactions were unaffected by whether samples were treated in H2 or H2S to form metal and sulfide clusters, respectively, before reaction. These data, taken together with the rate and extent of sulfur removal from us...

Heuristic Considerations Suggesting a Role for Electron Pairing in Thermodynamically Consistent Pathways of Enzyme Catalysis

A fundamental requirement for any satisfactory model of enzyme catalysis is that it allow for high specificity and speed in a way which is compatible with an energy balanced regeneration of the enzyme. The purpose of this paper is to point out that this requirement is fulfilled by a class of reaction schemes in which instabilities of electronic structure arise from short-lived resonances of par...

Multiplexed in vivo His-tagging of enzyme pathways for in vitro single-pot multienzyme catalysis.

Protein pathways are dynamic and highly coordinated spatially and temporally, capable of performing a diverse range of complex chemistries and enzymatic reactions with precision and at high efficiency. Biotechnology aims to harvest these natural systems to construct more advanced in vitro reactions, capable of new chemistries and operating at high yield. Here, we present an efficient Multiplex ...

Homogeneous Catalysis Homogeneous Catalysis

Nanoparticles for catalysis.